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PITRM1 Antibody

PITRM1 Antibody

Item no.	PRS-56-391-400ul
Manufacturer	ProSci
Amount	400 ul
Category	Oncology Antibodies By Cell Type Carcinoma Adenocarcinoma Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Presequence protease, mitochondrial, hPreP, 3424-, Pitrilysin metalloproteinase 1, Metalloprotease 1, hMP1, PITRM1, KIAA1104, MP1
Available
Shipping	blue ice or RT
By Research Area	Cell Cycle
Immunogen	This PITRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 490-518 amino acids from the Central region of human PITRM1.
Applications	For WB starting dilution is: 1:1000
Predicted Molecular Weight	117 kDa
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality	Polyclonal
Isotype	Rabbit Ig
Conjugate	Unconjugated
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	batch dependent
Storage Conditions	Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	PITRM1
Accession #	Q5JRX3
Protein Gi #	485956568
Ncbi Gene Id #	10531
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	PITRM1
Ncbi Official Full Name	Presequence protease, mitochondrial
Ncbi Organism	Homo sapiens
Swissprot #	Q5JRX3
Background	ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
Background References 1	Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Background References 2	Pinho, C.M., et al. Neurosci. Lett. 469(2):204-208(2010)
Background References 3	Oguri, M., et al. Am. J. Hypertens. 23(1):70-77(2010)
Background References 4	Yoshida, T., et al. Int. J. Mol. Med. 24(4):539-547(2009)
1st Image Caption	Western blot analysis in MDA-MB231 cell line lysates (35ug/lane).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 9/6/2024

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