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CDX2 Antibody

CDX2 Antibody

Item no.	PRS-5595-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Category	Oncology Antibodies Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Gastric Cancer
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IF, ELISA, IHC-P
Specific against	Human, Mouse, Rat
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CDX2 Antibody: CDX3, CDX-3, CDX3, Homeobox protein CDX-2
Available
Shipping	blue ice or RT
By Research Area	Homeostasis, Stem Cell
Homology	Predicted species reactivity based on immunogen sequence: Chicken: (94%), Bovine: (90%)
Immunogen	CDX2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human CDX2. The immunogen is located within amino acids 220 - 270 of CDX2.
Applications	CDX2 antibody can be used for detection of CDX2 by Western blot at 1 μ g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Positive Control 1	Cat. No. 1403 - Mouse Brain Tissue Lysate
Purification	CDX2 Antibody is affinity chromatography purified via peptide column.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	CDX2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/mL
Storage Conditions	CDX2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 5595P – CDX2 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	CDX2
Accession #	CAA74038
Protein Gi #	2193875
Ncbi Gene Id #	1045
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	CDX2
Ncbi Official Full Name	caudal type homeobox 2
Ncbi Organism	Homo sapiens
Swissprot #	Q99626
Background	CDX2 Antibody: CDX2 is a member of the caudal homeobox family of transcription factors that also includes the proteins CDX1 and CDX4. CDX2 is strongly expressed in the trophectoderm in the blastocyst with expression maintained within the proliferating extra-embryonic ectoderm during development. It is required for the repression of the transcription of the POU5F1/Oct4 and NANOG genes in the outer cells of the blastocyst and is thus essential for the segregation of the inner cell mass and trophectoderm at the blastocyst stage. Aberrant expression of CDX2 is associated with numerous types of carcinomas, including intestinal metaplasia, gastric carcinoma, and acute myeloid leukemia due to deregulated HOX gene expression.
Background References 1	Beck F, Erler T, Russell A, et al. Expression of CDX-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev. Dyn.1995; 204:219-27.
Background References 2	Strumpf D, Mao CA, Yamanaka Y, et al. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Dev.2005; 132:2093-102.
Background References 3	Ishikawa A, Sasaki M, Ohira S, et al. Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Lab. Invest.2004; 84:629-38.
Background References 4	Silberg DG, Sullivan J, Kang E, et al. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology2002; 122:689-96.
1st Image Caption	Western blot analysis of CDX2 in mouse brain tissue lysate with CDX2 antibody at 1 μ g/mL.
2nd Image Caption	Immunohistochemistry of CDX2 in rat brain tissue with CDX2 antibody at 5 μ g/mL.
3rd Image Caption	Immunofluorescence of CDX2 in rat brain tissue with CDX2 antibody at 20 μ g/mL.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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