TMEM18 Antibody

blue ice or RT

TMEM18 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM18.

The immunogen is located within the last 50 amino acids of TMEM18.

Cat. No. 1463 - Rat Brain Tissue Lysate

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 5043P – TMEM18 Peptide

None

Q96B42

129787

TMEM18

Homo sapiens

TMEM18 Antibody: Recent studies have examined how overexpression of certain genes enhances the tropism of neural stem cells (NSCs) for gliomas. Overexpression of Transmembrane protein 18 (TMEM18) provides NSCs and neural precursors an increased migration capacity towards glioblastoma cells in vitro and in the rat brain, while functional inactivation of the gene resulted in an almost complete loss of migration activity, suggesting that TMEM18 could be a potential target in NSC-based glioma therapy. Other recent results suggest that among others, the TMEM18 loci is associated with higher than normal body mass index (BMI) and obesity, indicating there may be a CNS-related role in predisposition to obesity. Multiple isoforms of TMEM18 are known to exist.

Willer CJ, Speliotes EK, Loos RJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet.2009; 41:25-34.

Western blot analysis of TMEM18 in rat brain lysate with TMEM18 antibody at (A) 0.5 and (B) 1 μ g/mL.

Immunofluorescence of TMEM18 in Mouse Brain cells with TMEM18 antibody at 20 μ g/mL.