Item no. |
PRS-50-182-0.1mL |
Manufacturer |
ProSci
|
Amount |
0.1 mL |
Category |
|
Type |
Antibody Primary |
Format |
Liquid |
Applications |
WB |
Specific against |
Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Available |
|
Shipping |
blue ice or RT |
Immunogen |
Peptide corresponding to amino acid residues from the C-terminal region of rat stargazin, conjugated to keyhole limpet hemocyanin (KLH). |
Applications |
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen. |
Predicted Molecular Weight |
36 |
Purification |
Affinity Purified |
Clonality |
Polyclonal |
Conjugate |
Unconjugated |
Storage Conditions |
Stargazin antibody can be stored at -20˚ C and is stable at -20˚ C for at least 1 year. |
Disclaimer |
This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
Cacng2 |
Accession # |
O88602 |
Protein Gi # |
6685280 |
Ncbi Gene Id # |
12300 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
Cacng2 |
Ncbi Official Full Name |
calcium channel, voltage-dependent, gamma subunit 2 |
Ncbi Organism |
Mus musculus |
Swissprot # |
O88602 |
Background |
Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002). |
Background References 1 |
Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS, (2005) Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435: 1052-1058. |
Background References 2 |
Priel A, Kolleker A, Ayalon G, Gillor M, Osten P, Stern-Bach Y. (2005) Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. J. Neurosci. 25, 2682–2686. |
Background References 3 |
Choi, J, Ko J, Park E, Lee JR, Yoon J, Lim S, Kim E, Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.J Biol Chem. 2002 Apr 5; 277(14):12359-63. |
1st Image Caption |
Western blot of rat synaptic membrane (SPM) showing specific immunolabeling of the ~ 36k stargazin protein. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.