Item no. |
PRS-4925-0.02mg |
Manufacturer |
ProSci
|
Amount |
0.02 mg |
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
ELISA, IHC-P |
Specific against |
Human |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
PTCHD2 Antibody: DISP3, DISP3, KIAA1337, Patched domain-containing protein 2, Protein dispatched homolog 3 |
Available |
|
Shipping |
blue ice or RT |
By Research Area |
Signal Transduction |
Immunogen |
PTCHD2 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human PTCHD2.
The immunogen is located within amino acids 210 - 260 of PTCHD2. |
Applications |
PTCHD2 antibody can be used for detection of PTCHD2 by immunohistochemistry at 5 μ g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. |
Specificity |
At least two isoforms of PTCHD2 are known to exist. This antibody is specific for PTCHD2 and will not recognize the other DISP family of proteins. |
Positive Control 1 |
Cat. No. 10-701 - Human Testis Tissue Slide |
Purification |
PTCHD2 Antibody is affinity chromatography purified via peptide column. |
Clonality |
Polyclonal |
Isotype |
IgG |
Conjugate |
Unconjugated |
Buffer |
PTCHD2 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration |
1 mg/mL |
Storage Conditions |
PTCHD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Related Products |
Cat. No. 4925P – PTCHD2 Peptide |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
PTCHD2 |
Accession # |
Q9P2K9 |
Protein Gi # |
149274653 |
Ncbi Gene Id # |
57540 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
PTCHD2 |
Ncbi Official Full Name |
patched domain containing 2 |
Ncbi Organism |
Homo sapiens |
Swissprot # |
Q9P2K9 |
Background |
PTCHD2 Antibody: PTCHD2, also known as DISP3, is the third of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored secreted proteins. Like DISP1 and DISP2, DISP3 has been implicated in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis. It is highly expressed in Purkinje cells, hippocampal neurons, and retinal ganglion cells. Recently, it has been shown that PTCHD2 localizes within the endoplasmic reticulum and colocalizes with cholesterol, and given that its expression is regulated by thyroid hormone (T3), it has been suggested that DISP3 may be a link between thyroid hormone and cholesterol metabolism. |
Background References 1 |
Katoh Y and Katoh M. Identification and characterization of DISP3 gene in silico. Int. J. Oncol. 2005; 26:551-6 |
Background References 2 |
Katoh Y and Katoh M. Hedgehog signaling pathway and gastric cancer. Can. Biol. & Ther. 2005; 4:1050-4 |
Background References 3 |
Zikova M, Corlett A, Bendova Z, et al. DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism. Mol. Endocrin. 2009; 23:520-8. |
1st Image Caption |
Immunohistochemistry of PTCHD2 in human testis tissue with PTCHD2 antibody at 5 μ g/mL. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.