LGP2 Antibody

blue ice or RT

LGP2 antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human LGP2.

The immunogen is located within amino acids 570 - 620 of LGP2.

At least four isoforms of LGP2 are known to exist.

Predicted: 70 kDa

Observed: 75 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 4351P – LGP2 Peptide

None

EAW60798

79132

DHX58

Homo sapiens

LGP2 Antibody: Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling.

Iwasaki A and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 2004; 5:987-95.

Andrejeva J, Childs KS, Young DF, et al. The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibits its activation of the IFN-betta promoter. Proc. Natl. Acad. Sci. USA, 2004; 101:17264-9.