SHP2 Antibody

Signal Transduction

SHP2 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human SHP2.

The immunogen is located within amino acids 510 - 560 of SHP2.

Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 3901P – SHP2 Peptide

None

NP_002825

5781

PTPN11

Homo sapiens

SHP2 Antibody: Src homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.

Ostman A, Hellberg C, and Bohmer FD. Protein-tyrosine phosphatases and cancer. Nat. Rev. Cancer 2006; 6:307-20.

Western blot analysis of SHP2 in mouse skeletal muscle tissue lysate with SHP2 antibody at (A) 0.5, (B) 1 and (C) 2 μ g/mL.