SOCS1 Antibody

blue ice or room temperature

Predicted: 23 kDa
Observed: 16 kDa

SOCS1 Antibody: The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.

SOCS1 Antibody is affinity chromatography purified via peptide column.

1 mg/ml

SOCS1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human SOCS1.

The immunogen is located within the last 50 amino acids of SOCS1.

suppressor of cytokine signaling 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.