Chromogranin A Antibody [CGA/413]

blue ice or RT

Recombinant human protein was used as the immunogen for the Chromogranin A antibody.

Does not react with rat

Monoclonal

IgG2b, kappa

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

None

1113

CHGA

Homo sapiens

Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Formalin-fixed, paraffin-embedded human parathyroid stained with Chromogranin A antibody (CGA/413)

Formalin-fixed, paraffin-embedded human adrenal gland stained with Chromogranin A antibody (CGA/413)