DEDAF Antibody

blue ice or RT

DEDAF antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DEDAF.

The immunogen is located within the last 50 amino acids of DEDAF.

Cat. No. 1203 - A549 Cell Lysate

Cat. No. 1404 - Mouse Liver Tissue Lysate

32 kDa

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 2227P – DEDAF Peptide

None

AF179286

23429

RYBP

Homo sapiens

DEDAF Antibody: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. Several molecules including caspases and adaptor FADD contain DEDs. A novel protein that interacts with DED of caspase-8 and 10, and FADD was identified recently and designated DEDAF for DED associated factor. DEDAF is identical to the transcriptional repressor RYBP. DEDAF/RYBP is expressed in multiple tissues and cell lines. DEDAF interacts with FADD and augments the formation of CD95/FADD/capase-8 complexes at the cell membrane, and interacts with DED-containing DNA biding protein (DEDD) in the nucleus indicating it is involved in the regulation of both cytoplasmic and nuclear events of apoptosis.

Garcia E, Marcos-Gutierrez C, del Mar Lorente M, et al. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 1999; 18:3404-18.

Immunohistochemistry of DEDAF in mouse liver tissue with DEDAF antibody at 5 μ g/mL.

Immunohistochemistry of DEDAF in mouse liver tissue with DEDAF antibody at 10 μ g/mL.