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DR6 Antibody

DR6 Antibody

Item no.	PRS-2157-0.02mg
Manufacturer	ProSci
Amount	0.02 mg
Category	Neuroscience Neuroinflammation Aging & Neurological Disorders Antibodies Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA
Specific against	Human
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	DR6 Antibody: DR6, CD358, BM-018, DR6, UNQ437/PRO868, Tumor necrosis factor receptor superfamily member 21, Death receptor 6
Available
Shipping	blue ice or RT
By Research Area	Apoptosis
Homology	Predicted species reactivity based on immunogen sequence: Rat: (73%), Mouse: (73%)
Immunogen	DR6 antibody was raised against a 15 amino acid peptide near the amino terminus of human DR6. The immunogen is located within amino acids 30 - 80 of DR6.
Applications	DR6 antibody can be used for detection of DR6 by Western blot at 1:500 dilution. An approximately 68 kDa band can be detected. Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1	Cat. No. 1201 - HeLa Cell Lysate
Positive Control 2	Cat. No. 1204 - K562 Cell Lysate
Predicted Molecular Weight	68 kDa
Purification	DR6 Antibody is Antibody is DEAE purified.
Clonality	Polyclonal
Isotype	IgG
Conjugate	Unconjugated
Buffer	DR6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Storage Conditions	DR6 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Related Products	Cat. No. 2157P – DR6 Peptide
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	TNFRSF21
Accession #	AF068868
Protein Gi #	3549262
Ncbi Gene Id #	27242
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	TNFRSF21
Ncbi Official Full Name	tumor necrosis factor receptor superfamily, member 21
Ncbi Organism	Homo sapiens
Swissprot #	O75509
Background	DR6 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κ B and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.
Background References 1	Pan G, Bauer JH, Haridas V, Wang S, Liu D, Yu G, Vincenz C, Aggarwal BB, Ni J, Dixit VM. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor. FEBS Lett 1998; 431:351-6
1st Image Caption	Western blot analysis of DR6 in K562 (1, 3) and Raji (2, 4) whole cell lysate in the absence (1, 2) or presence (3, 4) of blocking peptide (Catalog no. 2157P) with DR6 antibody at 1:500 dilution.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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