ATP1B1 Antibody

Cancer, Neuroscience, Signal Transduction

WB: 1:500 - 1:2000

IHC: 1:50 - 1:200

Polyclonal

Unconjugated

Store at -20˚ C. Avoid freeze / thaw cycles.

None

481

ATP1B1

Homo sapiens

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

Immunohistochemistry of paraffin-embedded human liver cancer using ATP1B1 antibody (15-288) at dilution of 1:100 (40x lens).