Ubiquitin Antibody [C9F7]

Apoptosis, Cell Cycle, Neuroscience

WB: 1:500 - 1:2000

IHC: 1:50 - 1:200

IF: 1:50 - 1:200

Affinity purification

[C9F7]

Unconjugated

Store at -20˚ C. Avoid freeze / thaw cycles.

None

7314

UBB

Homo sapiens

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in multiple transcript variants.

Immunohistochemistry of paraffin-embedded mouse brain using Ubiquitin antibody (13-957) at dilution of 1:100 (40x lens).

Immunohistochemistry of paraffin-embedded mouse placenta using Ubiquitin antibody (13-957) at dilution of 1:100 (40x lens).

Immunofluorescence analysis of MCF-7 cells using Ubiquitin antibody (13-957).