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CCND2 Antibody (OAAJ06391)

CCND2 Antibody (OAAJ06391)

Item no.	OAAJ06391
Manufacturer	AVIVA Systems Biology
Amount	100 uL
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Applications	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Gene symbol	CCND2
Protein name	G1/S-specific cyclin-D2
Molecular weight	33 kDa
Product format	Liquid
Gene id	894
Reconstitution and storage	Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
Description of target	Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex .
Purification	Immunogen affinity chromatography
Clonality	Polyclonal
Immunogen	A synthesized peptide derived from human Cyclin D2
Drywet	Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 uL

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Delivery expected until 9/27/2024

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