Item no. |
NKM-ATGA0369-50ul |
Manufacturer |
NKMAX
|
Amount |
50ul |
Category |
|
Type |
Antibody Monoclonal |
Clone |
AT14F5 |
Specific against |
other |
Host |
Mouse |
Isotype |
IgG2b kappa |
Conjugate/Tag |
Unconjugated |
NCBI |
NP_003893 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Far upstream element (FuSE) binding protein 1, FBP, FuBP |
Available |
|
Antigen Species |
Human |
Applications info |
ELISA, WB, ICC/IF |
Clonality Mono VS Poly |
Monoclonal |
Concentration |
1mg/ml |
Description |
FUBP1 is a transcriptional regulator and fulfills an important function in the precise control of c-myc transcription. The c-Myc protein is a transcription factor which regulates the transcription of many different target genes that play a role in proliferation, cell cycle progression, differentiation, apoptosis and cell metabolism. Consequently, FUBP1 is also involved in the regulation of proliferation and differentiation, as confirmed by different experimental approaches. Knockdown of FUBP1 or expression of a dominant-negative FUBP1 (DNA-binding domain lacking effector activity) led to proliferation arrest in U2OS and Saos-2 osteosarcoma cells due to reduced c-myc expression. |
Formulation |
Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. |
Gene Category |
Epigenomics (Transcription & Translation) |
General References |
Duncan R., et al. (1994) Genes Dev. 8(4): 465-480. Liu J., et al. (2006) EMBO J. 25(10): 2119-2130. |
Immunogen |
Recombinant human FUBP1 (279-448aa) purified from E.coli |
Reacts With |
Human |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Usage |
The antibody has been tested by ELISA, Western blot and ICC/IF analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.