Item no. |
NKM-ATGA0208-50ul |
Manufacturer |
NKMAX
|
Amount |
50ul |
Category |
|
Type |
Antibody Monoclonal |
Clone |
AT5E10 |
Specific against |
other |
Host |
Mouse |
Isotype |
IgG2b kappa |
Conjugate/Tag |
Unconjugated |
NCBI |
NP_004085 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Eukaryotic translation initiation factor 2 subunit 1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, Eukaryotic translation initiation factor 2 subunit 1 EIF 2 alpha, EIF 2, EIF 2A, EIF 2alpha, EIF2 alpha, Eukaryotic translation initiation factor 2 subunit 1 alpha 35kDa, Eukaryotic translation initiation factor 2 subunit 1 alpha, Eukaryotic translation initiation factor 2 subunit alpha. |
Available |
|
Antigen Species |
Human |
Applications info |
ELISA, WB, ICC/IF |
Clonality Mono VS Poly |
Monoclonal |
Concentration |
1mg/ml |
Description |
Eukaryotic translation initiation factor 2, subunit 1 alpha (EIF2S1) is plays a central role in initiating translation, and provides for a rate-limiting step in protein synthesis. The phosphorylation of alpha-subunit of EIF2S1 effectively prevents formation of the EIF2S1/GTP/Met-tRNAi complex and inhibits global protein synthesis. |
Formulation |
Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol. |
Gene Category |
Signal Transduction |
General References |
Kim JH, et al. (2011). EMBO J, 10 30(12):2454-64 Pena J, et al. (2011). J Biol Chem, 286(16):14226-36. Muaddi H, et al. (2010). Mol Biol Cell, 21(18):3220-31 |
Immunogen |
Recombinant human EIF2S1 (1-315aa) purified from E. coli |
Reacts With |
Human |
Storage |
Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles. |
Usage |
The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1, 000. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.