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Human TDP1 antibody

Human TDP1 antibody

Item no.	NKM-ATGA0157-100ul
Manufacturer	NKMAX
Amount	100ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Clone	AT1F2
Specific against	other
Host	Mouse
Isotype	IgG2b kappa
Conjugate/Tag	Unconjugated
NCBI	NP_060789
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	tyrosyl-DNA phosphodiesterase 1, FLJ11090, SCAN1
Available
Antigen Species	Human
Applications info	ELISA, WB, FACS, ICC/IF
Clonality Mono VS Poly	Monoclonal
Concentration	1mg/ml
Description	Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Gene Category	Cell Cycle
General References	Dexheimer TS, et al., (2008) Anticancer Agents Med Chem. 8(4):381-9 EI-Khamisy SF, Caldecott KW., (2006) Mutagenesis. 21(4):219-24
Immunogen	Recombinant human TDP1 (1-298aa) purified from E. coli
Reacts With	Human
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Usage	The antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ca. 2000. Recommended starting dilution is 1:1000.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ul

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