Anti-Mouse MAdCAM-1 - Purified

Antibody Details

Product Details

Reactivity Species

Mouse

Host Species

Rat

Immunogen

Mouse Endothelial Cells

Product Concentration

0.5 mg/ml

Formulation

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Storage and Handling

This purified antibody is stable when stored at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

RRID

AB_2831331

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Rat Anti-Mouse MAdCAM-1 (Clone MECA-367) recognizes an epitope on Mouse MAdCAM-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Background

Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a multifunctional type l transmembrane adhesion molecule that is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking.¹ MAdCAM-1 is involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract.² MAdCAM-1 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity.³

Antigen Details

Protein

MADCAM-1

Ligand/Receptor

Integrin a4ß7, CD62L

PubMed

MADCAM-1

NCBI Gene Bank ID

17123

UniProt.org

Information on Uniprot.org

Research Area

Cell Adhesion

.

Cell Biology

.

Immunology

References & Citations

1. Briskin MJ et al. (1995) J Immunol. 155: 2477
2. Jackson D et al. (1997) Immunol Res. 16: 299
3. Ringler DJ et al. (1997) Am J Pathol. 151: 97

Technical Protocols