Antibody Details
Product Details
Reactivity Species
Mouse
Host Species
Rat
Immunogen
Mouse Endothelial Cells
Product Concentration
0.5 mg/ml
Formulation
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day 2-8°C
RRID
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Description
Specificity
Rat Anti-Mouse MAdCAM-1 (Clone MECA-367) recognizes an epitope on Mouse MAdCAM-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background
Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a multifunctional type l transmembrane adhesion molecule that is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking.1 MAdCAM-1 is involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract.2 MAdCAM-1 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity.3
Antigen Details
Protein
MADCAM-1
Ligand/Receptor
Integrin a4ß7, CD62L
PubMed
MADCAM-1
NCBI Gene Bank ID
17123
UniProt.org
Information on Uniprot.org
Research Area
Cell Adhesion
.
Cell Biology
.
Immunology
References & Citations
1. Briskin MJ et al. (1995) J Immunol. 155: 24772. Jackson D et al. (1997) Immunol Res. 16: 2993. Ringler DJ et al. (1997) Am J Pathol. 151: 97
Technical Protocols