Anti-Mouse CD19 - FITC

Antibody Details

Product Details

Reactivity Species

Mouse

Host Species

Rat

Immunogen

Fusion of NS-1 Myeloma cells with spleen cells

Product Concentration

0.2 mg/ml

Formulation

This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Storage and Handling

This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

Excitation Laser

Blue Laser (490 nm)

RRID

AB_2829187

Applications and Recommended Usage?
Quality Tested by Leinco

B
IP
For specific conjugates of this clone, review literature for suggested application details.

Additional Reported Applications For Relevant Conjugates ?

B
IP
For specific conjugates of this clone, review literature for suggested application details.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Clone 1D3 recognizes an epitope on mouse CD19.

Antigen Distribution

CD19 is expressed in the majority of Pro-B cells to mature B cells (during development) and follicular dendritic cells. Plasma cells do not express CD19.

Background

CD19 is a 95 kD transmembrane glycoprotein and member of the Ig superfamily. The antigen serves as an adaptor protein; drawing cytoplasmic signaling proteins to the membrane. It works via the CD19/CD21 complex to decrease the threshold for B cell receptor signaling pathways. Because of its presence on all B cells, CD19 is a biomarker for B lymphocyte development, lymphoma diagnosis and can be utilized as a target for the immunotherapy of lymphoproliferative disorders. Emerging studies indicate that CD19 plays an active role in fueling the growth of these cancers, most notably by stabilizing the concentrations of the MYC oncoprotein, making CD19 an attractive therapeutic target with respect to its downstream signaling.

Antigen Details

Protein

CD19

Ligand/Receptor

CD21, CD81, Leu-13.

PubMed

CD19

NCBI Gene Bank ID

12478

UniProt.org

Information on Uniprot.org

Research Area

Immunology

References & Citations

1.) Skyberg, J. A. et al. (2020) Infection and Immunity. 88: 5 Journal Link

Technical Protocols