Antibody Details
Product Details
Reactivity Species
Human
Host Species
Mouse
Product Concentration
0.5 mg/ml
Formulation
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Storage and Handling
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Country of Origin
USA
Shipping
Next Day Ambient
RRID
Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Description
Specificity
Mouse Anti-Human CD61 (Clone F11) recognizes Human CD61. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Anti-CD61 recognizes the (Mr 110 kDa) common ß-subunit of the gp IIb/IIIa complex and the vitronectin receptor (VNR). The gp IIb (CD41) antigen and the gp IIIa (CD61) antigen form the cell adhesion complex (gp IIb/IIIa) which is the receptor on platelets for fibrinogen, von Willebrand factor, fibronectin and vitronectin.
Antigen Distribution
The CD61 antigen is present on virtually all resting and activated platelets. The antigen is also known to be present on endothelial cells, megakaryocytes and some leukemias of myeloid, erythroid and lymphoid origin.
Background
Anti-CD61 may be used to identify platelets and megakaryocytes. It may also be used in studies to characterize leukemias and in research of cell adhesion molecules.
Antigen Details
Protein
CD61
Ligand/Receptor
Fibronectin, vitronectin, vWF
PubMed
CD61
NCBI Gene Bank ID
3690
UniProt.org
Information on Uniprot.org
Research Area
Immunology
References & Citations
1. Helfrich, M. N. et al. submitted for publication
Technical Protocols