Item no. |
ICH5015-5MG |
Manufacturer |
IchorBio
|
Amount |
5mg |
Category |
|
Type |
Biosimilars |
Applications |
FA |
Specific against |
Human |
Isotype |
IgG1 |
Purity |
>95% by SDS-PAGE |
Citations |
Lee et al. A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. Journal of Experimental & Clinical Cancer Research |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
4-1BB ligand receptor, T-cell antigen 4-1BB, Tnfrsf9, Ila, Ly63, CD137 |
Available |
|
Specificity |
Detects human CD137. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Urelumab. This product is for research use only. |
Manufacturers Product Category |
Low endotoxin, biosimilar antibody |
Target Information |
4-1BB |
Isotype Information |
Human IgG1 |
Purification method |
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. |
Background |
RUO urelumab is a humanized agonistic monoclonal antibody targeting 4-1BB with potential immunostimulatory and antineoplastic activities. Urelumab specifically binds to and activates CD137-expressing immune cells, stimulating an immune response, in particular a cytotoxic T cell response, against tumor cells. . |
Concentration |
5mg/ml |
Formulation |
Sterile, preservative-free, solution in PBS. BSA and Azide free. |
Endotoxin |
≤ 1.0 EU/mg as determined by the LAL method |
Storage |
This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C. |
Application Notes |
This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients. |
Use |
Products are for research use only. Not for use in diagnostic or therapeutic procedures. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.