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Vedolizumab Biosimilar - Research Grade

Vedolizumab Biosimilar - Research Grade

Item no.	ICH4035-50MG
Manufacturer	IchorBio
Amount	50 mg
Quantity options	100 mg 10 mg 1 mg 20 mg 50 mg 5 mg
Category	Antibodies In Vivo Antibodies
Type	Biosimilars
Specific against	Human (Homo sapiens)
Host	Humanized
Isotype	IgG1
Purity	>95% by SDS-PAGE and HPLC
Citations	Dipasquale et al. Biosimilars in Pediatric IBD: Updated Considerations for Disease Management Parrish II, RH. Biosimilar Interchangeability and Emerging Treatment Strategies for Inflammatory Bowel Diseases: A Commentary. Gastroenterology Insights
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	ITGA4, ITGB7
Shipping condition	Cool pack
Available
Specificity	Detects human Integrin α4β7. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Vedolizumab. This product is for research use only.
Manufacturer - Category	Low endotoxin, Biosimilar, recombinant antibody
Manufacturer - Isotype	Human IgG1
Manufacturer - Targets	Integrin alpha 4 + beta 7
Manufacturer - Host	Humanized
Shipping Temperature	Blue ice
Storage Conditions	Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation	Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Background	Vedolizumab, an integrin receptor antagonist, is a humanized IgG1 monoclonal antibody produced in Chinese hamster ovary cells that binds to the human α4β7 integrin. Vedolizumab has an approximate molecular weight of 147 kilodaltons.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	Detects human Integrin alpha 4 + beta 7. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Vedolizumab.
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control	Bulk Human IgG1 Isotype Control (IB1) [ICH2254]
Buffer	ICH3001-100ml; ICH3002-100ml; ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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