Item no. |
ICH4031-5MG |
Manufacturer |
IchorBio
|
Amount |
5mg |
Category |
|
Type |
Biosimilars |
Specific against |
Human |
Host |
Humanized |
Isotype |
IgG1 Kappa |
Purity |
>95% by SDS-PAGE and HPLC |
Citations |
Gupta et al. Topical Delivery of Ranibizumab drops in Anti-aggregation diluent formula for retinal Delivery in Rabbits. ARVO Annual Meeting Abstract |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Vascular endothelial growth factor |
Available |
|
Specificity |
Detects human VEGF. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ranibizumab. This product is for research use only. |
Manufacturers Product Category |
Low endotoxin, biosimilar antibody |
Target Information |
VEGF |
Isotype Information |
Human IgG1 Kappa |
Host Information |
Humanized |
Purification method |
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. |
Background |
Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab, which lacks an Fc region, has a molecular weight of approximately 48 kilodaltons and is produced by CHO expression system. |
Concentration |
1.0 - 5.0 mg/ml |
Formulation |
Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free. |
Endotoxin |
≤ 0.5 EU/mg as determined by the LAL method |
Storage |
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles. |
Use |
Products are for research use only. Not for use in diagnostic or therapeutic procedures. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.