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Ranibizumab Biosimilar - Research Grade

Ranibizumab Biosimilar - Research Grade

Item no.	ICH4031-50MG
Manufacturer	IchorBio
Amount	50 mg
Quantity options	10 mg 20 mg 2 mg 50 mg 5 mg
Category	Antibodies In Vivo Antibodies
Type	Biosimilars
Specific against	Human (Homo sapiens)
Isotype	IgG1 Kappa
Purity	>95% by SDS-PAGE and HPLC
Citations	Gupta et al. Topical Delivery of Ranibizumab drops in Anti-aggregation diluent formula for retinal Delivery in Rabbits. ARVO Annual Meeting Abstract
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Vascular endothelial growth factor
Shipping condition	Cool pack
Available
Specificity	Detects human VEGF. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ranibizumab. This product is for research use only.
Manufacturer - Type	Low endotoxin, biosimilar antibody
Manufacturer - Category	Low endotoxin, Biosimilar, recombinant antibody
Manufacturer - Isotype	Human IgG1 Kappa
Manufacturer - Targets	VEGF
Manufacturer - Host	Humanized
Shipping Temperature	Blue ice
Storage Conditions	Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation	Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Background	Ranibizumab is a recombinant humanized IgG1 kappa isotype monoclonal antibody fragment designed for intraocular use. Ranibizumab binds to and inhibits the biologic activity of human vascular endothelial growth factor A (VEGF-A). Ranibizumab, which lacks an Fc region, has a molecular weight of approximately 48 kilodaltons and is produced by CHO expression system.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	Detects human VEGF. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Ranibizumab.
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control	Bulk Human IgG1 Isotype Control (IB1) [ICH2254]
Buffer	ICH3001-100ml; ICH3002-100ml; ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Delivery expected until 5/1/2025

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