Comparison

Denosumab Biosimilar - Research Grade European Partner

Item no. ICH4019-10MG
Manufacturer IchorBio
Amount 10 mg
Quantity options 100 mg 10 mg 1 mg 20 mg 50 mg 5 mg
Category
Type Biosimilars
Specific against Human (Homo sapiens)
Host Humanized
Isotype IgG
Purity >95% by SDS-PAGE and HPLC
Citations RANKL neutralisation prevents
osteoclast activation in a human in vitro
ameloblastoma-bone model
Narsimhan et al. Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies. Analytical Chemistry
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Tumor necrosis factor ligand superfamily member 11, Tnfsf11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine, TRANCE, CD254, Rank Ligang
Shipping condition Cool pack
Available
Specificity Detects human RANK Ligand. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Denosumab. This product is for research use only.
Manufacturer - Category
Low endotoxin, Biosimilar, recombinant antibody
Manufacturer - Isotype
Human IgG2
Manufacturer - Targets
RANKL
Manufacturer - Host
Humanized
Shipping Temperature
Blue ice
Storage Conditions
Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation
Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Background
Denosumab biosimilar is a human IgG2 monoclonal antibody that binds to human RANKL. Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells.
Concentration
1.0 - 5.0 mg/ml
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity
Detects human RANK Ligand. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Denosumab.
Purification method
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control
Bulk Human IgG2 Isotype Control (IB2) [ICH2255]
Buffer
ICH3001-100ml
ICH3002-100ml
ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 mg
Available: In stock
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