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Ado-Trastuzumab Emtansine Biosimilar - Research Grade

Ado-Trastuzumab Emtansine Biosimilar - Research Grade

Item no.	ICH4014-1EA
Manufacturer	IchorBio
Amount	1 ea
Quantity options	1 ea 20 mg 5 mg
Category	Antibodies In Vivo Antibodies
Type	Biosimilars
Specific against	Human (Homo sapiens)
Host	Humanized
Isotype	IgG1
Purity	>95% by SDS-PAGE and HPLC
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Receptor tyrosine-protein kinase erbB-2, MLN 19, HER2, HER2/neu
Shipping condition	Cool pack
Available
Specificity	Detects human HER2. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Ado-trastuzumab emtansine. This product is for research use only.
Manufacturer - Category	Low endotoxin, Biosimilar, ADC, recombinant antibody
Manufacturer - Isotype	Human IgG1
Manufacturer - Targets	HER2
Manufacturer - Host	Humanized
Shipping Temperature	Blue ice
Storage Conditions	Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Formulation	Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Background	Ado-trastuzumab emtansine is a HER2-targeted antibody-drug conjugate which contains the humanized anti-HER2 IgG1, trastuzumab, covalently linked to the microtubule inhibitory drug DM1 via the stable thioether linker MCC. Trastuzumab is produced by Chinese hamster ovary cells, and DM1-MCC are produced by chemical synthesis. Ado-trastuzumab emtansine contains an average of 3.5 DM1 molecules per antibody.
Concentration	1.0 - 5.0 mg/ml
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	Detects human HER2. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Ado-trastuzumab emtansine.
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Isotype Control	Bulk Human IgG1 Isotype Control (IB1) [ICH2254]
Buffer	ICH3001-100ml; ICH3002-100ml; ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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