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Nivolumab Biosimilar - Research Grade

Nivolumab Biosimilar - Research Grade

Item no.	ICH4009-5MG
Manufacturer	IchorBio
Amount	5mg
Category	Antibodies In Vivo Antibodies
Type	Biosimilars
Specific against	Human
Host	Humanized
Isotype	IgG4 Kappa
Purity	>95% by SDS-PAGE and HPLC
Citations	Narsimhan et al. Mobile Affinity Selection Chromatography Analysis of Therapeutic Monoclonal Antibodies. Analytical Chemistry
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Programmed cell death protein 1, Pdcd1, CD279
Available
Specificity	Detects human PD-1. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Nivolumab. This product is for research use only.
Manufacturers Product Category	Low endotoxin, biosimilar antibody
Target Information	PD-1
Isotype Information	IgG4 kappa
Host Information	Humanized
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background	Nivolumab biosimilar is a human monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. Nivolumab is an IgG4 kappa immunoglobulin that has a calculated molecular mass of 146 kDa. It is expressed in a recombinant Chinese Hamster Ovary (CHO) cell line.
Concentration	1.0 - 5.0 mg/ml
Formulation	Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Endotoxin	≤ 0.5 EU/mg as determined by the LAL method
Storage	Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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Delivery expected until 12/20/2024

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