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Eculizumab Biosimilar - Research Grade

Eculizumab Biosimilar - Research Grade

Item no.	ICH4005-5MG
Manufacturer	IchorBio
Amount	5mg
Category	Antibodies In Vivo Antibodies
Type	Biosimilars
Specific against	Human
Host	Humanized
Isotype	IgG2
Purity	>95% by SDS-PAGE and HPLC
Citations	SARS-CoV-2 triggers complement activation through interactions with heparan sulfate
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	C5
Available
Specificity	Detects human Complement protein C5. This non-therapeutic antibody uses the same variable region sequence as the therapeutic antibody Eculizumab. This product is for research use only.
Manufacturers Product Category	Low endotoxin, biosimilar antibody
Isotype Information	IgG2/4 kappa
Host Information	Humanized
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Background	Eculizumab biosimilar is a recombinant humanized monoclonal IgG2/4κ antibody produced by Chinese hamster ovary cell culture and purified by standard bioprocess technology. Eculizumab biosimilar contains human constant regions from human IgG2 sequences and human IgG4 sequences and murine complementarity-determining regions grafted onto the human framework light- and heavy-chain variable regions. Eculizumab biosimilar is composed of two 448 amino acid heavy chains and two 214 amino acid light chains and has a molecular weight of approximately 148 kDa.
Concentration	1.0 - 5.0 mg/ml
Formulation	Phosphate buffered saline (PBS) pH 7.2, with no carrier protein, potassium or preservatives added. BSA and Azide free.
Endotoxin	≤ 0.5 EU/mg as determined by the LAL method
Storage	Stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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Delivery expected until 12/20/2024

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