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Anti-Mouse PD-L1 In Vivo Antibody - Low Endotoxin (10F.9G2)

Anti-Mouse PD-L1 In Vivo Antibody - Low Endotoxin (10F.9G2)

Item no.	ICH1086-5MG
Manufacturer	IchorBio
Amount	5mg
Category	Oncology Antibodies In Vivo Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Melanoma Sarcoma Mesothelioma Flow Cytometry Blocking
Type	Antibody
Applications	FC, IHC, Blocking, FA
Clone	10F.9G2
Specific against	Mouse
Host	Rat
Isotype	IgG2b Kappa
Purity	>95% by SDS-PAGE and HPLC
Citations	p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells Chen et al. NAT10/ac4C/FOXP1 Promotes Malignant Progression and Facilitates Immunosuppression by Reprogramming Glycolytic Metabolism in Cervical Cancer. Advanced Science Lin et al. Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice. Cell Reports
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Programmed cell death 1 ligand 1, Cd274, PDCD1 ligand 1, Programmed death ligand 1, B7 homolog 1, B7-H1, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1
Available
Specificity	Anti-PD-L1 In Vivo Antibody - Low Endotoxin (10F.9G2) recognizes an epitope on Mouse CD274
Manufacturers Product Category	Low Endotoxin, anti-mouse
Target Information	PD-L1
Isotype Information	Rat IgG2b Kappa
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution	The CD274 antigien is present on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes
Background	CD274, also known as B7-H1 and PD-L1, is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes.
Immunogen	Unknown
Concentration	1.0 - 5.0 mg/ml
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Endotoxin	<1.0 EU/mg as determined by the LAL method
Aggregation	Aggregation level ≤ 5%
Storage	anti-PD-L1 In Vivo Antibody - Low Endotoxin (10F.9G2) is stable when stored at 2-8°C. Do not freeze.
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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Delivery expected until 12/20/2024