Comparison

Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin European Partner

Item no. ICH1085-5MG
Manufacturer IchorBio
Amount 5 mg
Quantity options 100 mg 1 mg 25 mg 50 mg 5 mg
Category
Type Antibody
Applications WB, FC, IP, FA
Clone UC10-4F10-11
Specific against Mouse (Murine, Mus musculus)
Host Hamster - Armenian
Isotype IgG
Purity >95% by SDS-PAGE and HPLC
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Ctla4, Cytotoxic T-lymphocyte protein 4, CD152
Shipping condition Cool pack
Available
Specificity Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) recognizes an epitope on Mouse CD152
Manufacturer - Applications
Flow Cytometry, Western Blot, Functional Assays, Immunoprecipitation
Manufacturer - Category
Low Endotoxin, anti-mouse, monoclonal antibody
Manufacturer - Isotype
Armenian Hamster IgG1 Kappa
Manufacturer - Targets
CTLA-4
Shipping Temperature
Blue ice
Storage Conditions
anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.
Aggregation
Aggregation level ≤ 5%
Formulation
0.01 M phosphate buffered saline (PBS) pH 7.4, without BSA or sodium azide added.
Antigen Distribution
The UC10-4F10-11 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor.
Application Notes
Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
Each investigator should determine their own optimal working dilution for specific applications.
Background
CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
Concentration
≥ 2.0 mg/ml
Endotoxin
≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity
Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) recognizes an epitope on Mouse CD152
Purification method
This monoclonal antibody was purified using Protein A
Use
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Immunogen
Purified Recombinant Mouse CTLA4 Fc Fusion Protein
Antibodies against the same target (Cat No.)
Isotype Control
Armenian Hamster IgG Isotype Control for In Vivo - Low Endotoxin [PIP] (ICH2251)
Buffer
ICH3001-100ml
ICH3002-100ml
ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 5 mg
Available: In stock
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