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Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin

Anti-Mouse CTLA-4 (UC10-4F10-11) In Vivo Antibody - Low Endotoxin

Item no.	ICH1085-50MG
Manufacturer	IchorBio
Amount	50 mg
Quantity options	100 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Antibodies In Vivo Antibodies By Cell Type Carcinoma Flow Cytometry Western Blot
Type	Antibody
Applications	WB, FC, IP, FA
Clone	UC10-4F10-11
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Isotype	IgG
Purity	>95% by SDS-PAGE and HPLC
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ctla4, Cytotoxic T-lymphocyte protein 4, CD152
Shipping condition	Cool pack
Available
Specificity	Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) recognizes an epitope on Mouse CD152
Manufacturer - Applications	Flow Cytometry, Western Blot, Functional Assays, Immunoprecipitation
Manufacturer - Category	Low Endotoxin, anti-mouse, monoclonal antibody
Manufacturer - Isotype	Armenian Hamster IgG1 Kappa
Manufacturer - Targets	CTLA-4
Shipping Temperature	Blue ice
Storage Conditions	anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) is stable when stored at 2-8°C. Do not freeze.
Aggregation	Aggregation level ≤ 5%
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.4, without BSA or sodium azide added.
Antigen Distribution	The UC10-4F10-11 antibody reacts with CD152 (CTLA-4), which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor.
Application Notes	Functional Assay: Clone UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. Each investigator should determine their own optimal working dilution for specific applications.
Background	CD152, also known as CTLA-4 or Ly-56 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.
Concentration	≥ 2.0 mg/ml
Endotoxin	≤ 1.0 EU/mg as determined by the LAL method
Manufacturer - Specificity	Anti-CTLA-4 In Vivo Antibody - Low Endotoxin (UC10-4F10-11) recognizes an epitope on Mouse CD152
Purification method	This monoclonal antibody was purified using Protein A
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.
Immunogen	Purified Recombinant Mouse CTLA4 Fc Fusion Protein
Antibodies against the same target (Cat No.)	ICH1084-100MG, ICH1096UL-100MG, ICH1096-100MG, ICH1084UL-100MG
Isotype Control	Armenian Hamster IgG Isotype Control for In Vivo - Low Endotoxin [PIP] (ICH2251)
Buffer	ICH3001-100ml ICH3002-100ml ICH3003-100ml

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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Delivery expected until 2/7/2025

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