Item no. |
ICH1084UL-50MG |
Manufacturer |
IchorBio
|
Amount |
50 mg |
Quantity options |
100 mg
25 mg
50 mg
5 mg
|
Category |
|
Type |
Antibody |
Applications |
WB, FC, ELISA, Blocking |
Clone |
9H10 |
Specific against |
Mouse (Murine, Mus musculus) |
Host |
Hamster - Syrian |
Isotype |
IgG |
Purity |
>98% by SDS-PAGE and HPLC |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Ctla4, Cytotoxic T-lymphocyte protein 4, CD152 |
Shipping condition |
Cool pack |
Available |
|
Specificity |
Anti-CTLA-4 In Vivo Antibody - Ultra Low Endotoxin (9H10) recognizes an epitope on Mouse CTLA-4 |
Manufacturer - Applications |
Western Blot, Blocking, ELISA, Flow Cytometry |
Manufacturer - Category |
Ultra-Low Endotoxin, anti-mouse, monoclonal antibody |
Manufacturer - Isotype |
Syrian Hamster IgG |
Manufacturer - Targets |
CTLA-4 |
Shipping Temperature |
Blue ice |
Storage Conditions |
anti-CTLA-4 In Vivo Antibody - Ultra Low Endotoxin (9H10) is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles. |
Aggregation |
Aggregation level ≤ 1% |
Formulation |
0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added. |
Antigen Distribution |
Activated T cells |
Application Notes |
Each investigator should determine their own optimal working dilution for specific applications. |
Background |
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. Clone 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA4 binding, allowing for CD28 binding. |
Concentration |
1.0 - 5.0 mg/ml |
Endotoxin |
≤ 0.5 EU/mg as determined by the LAL method |
Manufacturer - Specificity |
Anti-CTLA-4 In Vivo Antibody - Ultra Low Endotoxin (9H10) recognizes an epitope on Mouse CTLA-4 |
Purification method |
This monoclonal antibody was purified using Protein A |
Use |
Products are for research use only. Not for use in diagnostic or therapeutic procedures. |
Immunogen |
Mouse CTLA-4-human IgG1 fusion protein |
IMPACT Pathogen Test |
We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our hamster antibodies are tested for: Mycoplasma spp Mycoplasma pulmonis Pneumonia virus of mice Kilham's rat virus Toolan's H1 virus Hamster parvovirus Lymphocytic choriomeningitis Minute virus of mice Theiler's murine encephalomyelitis virus Sendai virus Reovirus 3 Hantaan virus |
Related Antibodies |
|
Antibodies against the same target (Cat No.) |
|
Buffer |
ICH3001-100ml ICH3002-100ml ICH3003-100ml |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.