Anti-Mouse CD120a (55R-593) In Vivo Antibody - Low Endotoxin

Immunoprecipitation, Western Blot

Armenian Hamster IgG1

Blue ice

Aggregation level ≤ 5%

Variety of cell types at low levels

Tumor Necrosis Factor Receptor Type I (TNFRI) is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-A and TNF-B (also known as LT-A). The subsequent signaling is known to be important for inducing cytolytic activity, antiviral activity, expression of manganous superoxide dismutase and intercellular adhesion molecule (ICAM), IL-6 mRNA accumulation and NF-ĸB induction. TNFRI carries an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein). Binding of 55R-170 antibody to TNFRI has been shown to block in vitro and in vivo receptor signaling initiated by ligand binding.

≤ 1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein A

E. coli-expressed extracellular domain of the mouse TNFRI protein

Armenian Hamster IgG Isotype Control for In Vivo - Low Endotoxin [PIP] (ICH2251)