Item no. |
ICH1068-1MG |
Manufacturer |
IchorBio
|
Amount |
1mg |
Category |
|
Type |
Antibody |
Applications |
WB, Blocking |
Clone |
AFS98 |
Specific against |
Mouse |
Host |
Rat |
Isotype |
IgG2a Kappa |
Purity |
>95% by SDS-PAGE and HPLC |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
in vivo |
Available |
|
Specificity |
Anti-CD115 In Vivo Antibody - Low Endotoxin (AFS98) recognizes an epitope on Mouse M-CSFR |
Aggregation |
Aggregation level <= 5% |
Antigen Distribution |
Monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, osteoclasts |
Application Notes |
Each investigator should determine their own optimal working dilution for specific applications. |
Background |
Macrophage colony-stimulating factor (M-CSF, also termed CSF-1) receptor is an integral membrane tyrosine kinase, expressed in monocytes (macrophages and their progenitors) and drives growth and development of this blood cell lineage. It also triggers growth and development of mononuclear phagocytes and placental trophoblasts. M-CSF receptor is present in osteoclasts both at mRNA and protein levels. When M-CSF ligand specifically binds to the M-CSF receptor on osteoclasts, it induces receptor dimerization, activation and autophosphorylation of cytoplasmic tyrosine residues M-CSF and its receptor present as candidate therapeutic targets in states of inflammatory bone erosion. |
Concentration |
1.0 - 5.0 mg/ml |
Endotoxin |
<= 1.0 EU/mg as determined by the LAL method |
Formulation |
0.01 M phosphate buffered saline (PBS), pH 7.2 - 7.4 without azide or BSA. |
Immunogen |
Purified Recombinant Mouse M-CSFR |
Product Type |
Low Endotoxin, anti-mouse |
Purification method |
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. |
Storage |
anti-CD115 In Vivo Antibody - Low Endotoxin (AFS98) is stable when stored at 2-8C. For long term storage aseptically aliquot in working volumes without diluting and store at -80C. Avoid Repeated Freeze Thaw Cycles. and keep sterile. |
Use |
Products are for research use only. Not for use in diagnostic or therapeutic procedures. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.