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Bulk anti-Human CD119 antibody (GIR 208)

Bulk anti-Human CD119 antibody (GIR 208)

Item no.	ICH1028UL-100MG
Manufacturer	IchorBio
Amount	100mg
Category	Oncology Antibodies In Vivo Antibodies By Cell Type Melanoma Western Blot Blocking
Type	Antibody
Applications	WB, IP, Blocking, FA
Clone	GIR 208
Specific against	Human
Host	Mouse
Isotype	IgG1
Purity	>98% by SDS-PAGE and HPLC
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Interferon gamma receptor 1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain2, IFN-gamma-R-alpha
Available
Specificity	Anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) recognizes Human IFN gamma R alpha
Manufacturers Product Category	Ultra-Low Endotoxin, anti-human
Target Information	CD119
Isotype Information	Mouse IgG1
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution	The IFN-gamma receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.
Background	Interferon-gamma (IFN-gamma) exerts its biologic effects by interacting with a single high affinity receptor, IFN-gamma receptor. This receptor is present on almost all cell types except mature erythrocytes. The IFN-gamma receptor consists of two polypeptide chains alpha and beta and requires association of JAK1, JAK2 and Stat1 for IFN-gamma signal transduction. In signal transduction, IFN-gamma induces tyrosine phosphorylation of IFN-gamma receptor alpha (IFNGR1) leading to the formation of a docking site on the activated receptor for Stat1, which specifically activates IFN-gamma induced gene transcription. The IFN-gamma receptor is structurally related to the recently cloned IL-10 receptor. GIR 208 binds IFNGR1 and blocks binding of IFN-gamma to the receptor.
Immunogen	Human IFN-gamma R alpha, Purified from human placenta
Concentration	1.0 - 5.0 mg/ml
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Endotoxin	≤ 0.5 EU/mg as determined by the LAL method
Aggregation	Aggregation level ≤ 1%
IMPACT Pathogen Test	We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: - Mycoplasma spp. - Mycoplasma pulmonis - Sendai virus - Mouse hepatitis virus - Pneumonia virus of mice - Minute virus of mice - Mouse parvovirus (MPV1-5) - Theiler's murine encephalomyelitis virus - Murine norovirus - Reovirus 3 - Mouse rotavirus - Ectromelia virus - Lymphocytic choriomeningitis virus - Polyoma virus - Lactate dehydrogenase-elevating virus - Mouse adenovirus (MAD1, MAD2) - Mouse cytomegalovirus - K virus - Mouse thymic virus - Hantaan virus - Corynebacterium bovis - Corynebacterium spp. (HAC2)
Storage	anti-CD119 In Vivo Antibody - Ultra Low Endotoxin (GIR 208) is stable when stored at 2-8°C. For long term storage we recommended to store at -80°C.
Application Notes	Functional Assay: Clone GIR-208 can be used as an isotype with Clone MAR1-5A3 (Anti-Mouse IFNAR1) - Each investigator should determine their own optimal working dilution for specific applications.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100mg

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Delivery expected until 12/20/2024