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Anti-ICAM-1 In Vivo Antibody - Ultra Low Endotoxin (15.2) [ICH1027]

Anti-ICAM-1 In Vivo Antibody - Ultra Low Endotoxin (15.2) [ICH1027]

Manufacturer	IchorBio
Category	Oncology Neuroscience Neural Lineage Markers Antibodies In Vivo Antibodies By Cell Type Hematology Myeloma Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Western Blot
Type	Antibody
Specific against	Human, Mouse, Rat
Clone	15, 2
Isotype	IgG1
Applications	WB, FC, IP, IHC
Amount	5mg
Host	Mouse
Item no.	ICH1027UL-5MG
Targets	ICAM1
eClass 6.1	32160702
eClass 9.0	32160702
Available
Alias	Intercellular adhesion molecule 1, ICAM1, Major group rhinovirus receptor, CD54
Purity	>98% by SDS-PAGE and HPLC
Manufacturers Product Category	Ultra-Low Endotoxin
Target Information	ICAM-1
Isotype Information	Mouse IgG1
Purification method	This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution	The CD54 antigen is a membrane glycoprotein with a wide tissue distribution that includes vascular endothelium and many cells of the immune system. CD54 is weakly expressed on resting peripheral blood lymphocytes. Upon activation by mitogens, the CD54 antigen is strongly expressed on B-cells, T-cells, macrophages and granulocytes. CD54 is the receptor for rhinoviruses and malaria.
Background	Intercellular adhesion molecule-1 (ICAM-1) is one of an important cell adhesion molecules (CAMs) family transmembrane glycoprotein and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. ICAM-1 is a marker of endothelial dysfunction leading to damaging vascular disorders, in umbilical and placental vascular tissue of gestational pregnancies.
Immunogen	Human infant thymocytes and Sezary cells
Concentration	1.0 - 5.0 mg/ml
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Endotoxin	≤ 0.5 EU/mg as determined by the LAL method
Aggregation	Aggregation level ≤ 1%
IMPACT Pathogen Test	We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: - Mycoplasma spp. - Mycoplasma pulmonis - Sendai virus - Mouse hepatitis virus - Pneumonia virus of mice - Minute virus of mice - Mouse parvovirus (MPV1-5) - Theiler’s murine encephalomyelitis virus - Murine norovirus - Reovirus 3 - Mouse rotavirus - Ectromelia virus - Lymphocytic choriomeningitis virus - Polyoma virus - Lactate dehydrogenase-elevating virus - Mouse adenovirus (MAD1, MAD2) - Mouse cytomegalovirus - K virus - Mouse thymic virus - Hantaan virus - Corynebacterium bovis - Corynebacterium spp. (HAC2)
Storage	This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Application Notes	Each investigator should determine their own optimal working dilution for specific applications.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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Delivery expected until 8/2/2024

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