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anti- ECD antibody

anti- ECD antibody

Item no.	FNab10368-100ug
Manufacturer	FineTest
Amount	100ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Specific against	Human
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	ECD, GCR2, HSGT1, Protein ecdysoneless homolog, Protein SGT1, SGT1, Suppressor of GCR2
Available
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Clonality	polyclonal
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP(PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes(PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins(PubMed:19640839). The cell cycle-regulating function may depend on its RUVBL1-mediated association with the R2TP complex(PubMed:26711270). May play a role in regulation of pre-mRNA splicing(PubMed:24722212).
Immunogen	ecdysoneless homolog(Drosophila)
Observed MW	70-100 kDa
Uniprot ID	O95905
Tested Application	ELISA, WB, IHC
Recommended dilution	WB: 1:500-1:2000; IHC: 1:20-1:200
Gene ID	11319
Research Area	Metabolism

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ug

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