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anti- LARGE antibody

anti- LARGE antibody

Item no.	FNab04697-100ug
Manufacturer	FineTest
Amount	100ug
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Specific against	Human, Mouse
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	KIAA0609, LARGE1
Available
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Clonality	polyclonal
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Bifunctional glycosyltransferase with both xylosyltransferase and beta-1, 3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide(N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan(DAG1)(PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1, 4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1, 3-GlcA-beta-1-] to produce a heteropolysaccharide(PubMed:25279699).
Immunogen	like-glycosyltransferase
Observed MW	65-70 kDa
Uniprot ID	O95461
Tested Application	ELISA, WB
Recommended dilution	WB: 1:500-1:2000
Gene ID	9215
Research Area	Metabolism

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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