Item no. |
E18-0568-1 |
Manufacturer |
Enogene
|
Amount |
50ug/50ul |
Category |
|
Type |
Antibody |
Applications |
Immunofluorescence, Western Blot, Immunocytochemistry |
Specific against |
Human, Mouse, Rat |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Cardiac lineage protein 1, CLP1, EDG1, Estrogen down-regulated gene 1 protein, FLJ13562, hexamethylene bis-acetamide inducible 1, Hexamethylene bis-acetamide-inducible protein 1, hexamethylene bisacetamide-inducible protein, hexamethylene-bis-acetamide-in |
Available |
|
Background |
HEXIM1 Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. |
Swiss-Prot No. |
O94992 |
Form of Antibody |
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 C.Stable for 12 months from date of receipt |
Immunogen |
A synthesized peptide derived from human HEXIM1 |
Purification |
Immunogen affinity purified |
Specificity/Sensitivity |
HEXIM1 Antibody detects endogenous levels of HEXIM1 |
Applications information |
WB 1:500-1:2000 IF/ICC 1:100-1:500 |
Molecular Weight |
40kDa |
Storage/Stability |
Store at -20C/1 year |
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