Item no. |
CSB-RA567382A0HU-100ul |
Manufacturer |
Cusabio
|
Amount |
100ul |
Quantity options |
100ul
50ul
|
Category |
|
Type |
Antibody Monoclonal |
Format |
Liquid |
Applications |
IHC, ELISA |
Clone |
8B10 |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Survival motor neuron protein (Component of gems 1) (Gemin-1), SMN1, SMN2, SMN SMNT, SMNC, Survival motor neuron protein (Component of gems 1) (Gemin-1), SMN1, SMN2, SMN SMNT, SMNC |
Similar products |
SMN1, SMN2, SMNC, Survival motor neuron protein (Component of gems 1) (Gemin-1), SMN SMNT |
Available |
|
UniProt ID |
Q16637 |
Immunogen |
A synthesized peptide derived from human SMN1 |
Tested Applications |
ELISA, IHC; Recommended dilution: IHC:1:50-1:200 |
Background |
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). |
Conjugate |
Non-conjugated |
Buffer |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage |
Upon receipt, store at -20CC or -80CC. Avoid repeated freeze. |
Purification Method |
Affinity-chromatography |
Modified |
Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.