Item no. |
CSB-RA296617A0HU-100ul |
Manufacturer |
Cusabio
|
Amount |
100ul |
Quantity options |
100ul
50ul
|
Category |
|
Type |
Antibody Monoclonal |
Format |
Liquid |
Applications |
WB, IHC, ELISA |
Clone |
4B2 |
Specific against |
Human, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIFM1, AIF PDCD8, Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIFM1, AIF PDCD8 |
Similar products |
AIFM1, Apoptosis-inducing factor 1, mitochondrial (EC 1.1.1.-) (Programmed cell death protein 8), AIF PDCD8 |
Available |
|
UniProt ID |
O95831 |
Immunogen |
A synthesized peptide derived from human AIF |
Tested Applications |
ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200 |
Background |
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. |
Conjugate |
Non-conjugated |
Buffer |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage |
Upon receipt, store at -20CC or -80CC. Avoid repeated freeze. |
Purification Method |
Affinity-chromatography |
Modified |
Epigenetics and Nuclear Signaling; Cancer; Cell biology; Metabolism |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.