Item no. |
CSB-RA010097A139phHU |
Manufacturer |
Cusabio
|
Amount |
100ul |
Quantity options |
100ul
50ul
|
Category |
|
Type |
Antibody Monoclonal |
Format |
Liquid |
Applications |
WB, ELISA |
Clone |
1F10 |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX, Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX |
Similar products |
H2AFX, H2AX, H2a/x, Histone H2AX, Histone H2A.X |
Available |
|
UniProt ID |
P16104 |
Immunogen |
A synthesized peptide |
Tested Applications |
ELISA, WB; Recommended dilution: WB:1:3000-1:10000 |
Background |
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. |
Conjugate |
Non-conjugated |
Buffer |
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage |
Upon receipt, store at -20CC or -80CC. Avoid repeated freeze. |
Purification Method |
Affinity-chromatography |
Modified |
Epigenetics and Nuclear Signaling |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.