Item no. |
CSB-PA853467LC01HU-50ug |
Manufacturer |
Cusabio
|
Amount |
50ug |
Quantity options |
100ug
50ug
|
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Conjugate/Tag |
FITC |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
YTHDC1 antibody; KIAA1966 antibody; YT521 antibody; YTH domain-containing protein 1 antibody; Splicing factor YT521 antibody; YT521-B antibody, YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B), YTHDC1, KIAA1966 YT521 |
Similar products |
YTHDC1, YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B), KIAA1966 YT521 |
Available |
|
Immunogen Species |
Human |
UniprotID |
Q96MU7 |
Immunogen |
Recombinant Human YTH domain-containing protein 1 protein (89-153AA) |
Applications info |
ELISA |
Background |
Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (PubMed:26318451, PubMed:26876937, PubMed:25242552). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:26318451, PubMed:25242552). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (PubMed:26876937). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing (PubMed:26876937). In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May also regulate alternative splice site selection (PubMed:20167602). |
Conjugate |
FITC |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Epigenetics and Nuclear Signaling |
Initial Research Areas |
Epigenetics and Nuclear Signaling |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.