Item no. |
CSB-PA613425LA01HU-50ug |
Manufacturer |
Cusabio
|
Amount |
50ug |
Quantity options |
100ug
20ug
50ug
|
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
IF, IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
C22orf19 antibody; Chromosome 22 open reading frame 19 antibody; Fmip antibody; Fms interacting protein antibody; fSAP79 antibody; Functional spliceosome-associated protein 79 antibody; hTREX90 antibody; KIAA0983 antibody; LOC400922 antibody; NF2/meningioma region protein pK1.3 antibody; PK1.3 antibody; Placental protein 39.2 antibody; PP39.2 antibody; THO complex 5 antibody; THO complex subunit 5 antibody; THO complex subunit 5 homolog antibody; thoc5 antibody; THOC5_HUMAN antibody, THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90), THOC5, C22orf19 KIAA0983 |
Similar products |
THOC5, THO complex subunit 5 homolog (Functional spliceosome-associated protein 79) (fSAP79) (NF2/meningioma region protein pK1.3) (Placental protein 39.2) (PP39.2) (hTREX90), C22orf19 KIAA0983 |
Available |
|
Immunogen Species |
Human |
UniprotID |
Q13769 |
Immunogen |
Recombinant Human THO complex subunit 5 homolog protein (2-53AA) |
Applications info |
ELISA, IHC, IF, Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
IHC:1:200-1:500 |
Dilution ratio 3 |
IF:1:50-1:200 |
Background |
Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes. |
Conjugate |
Non-conjugated |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Immunology |
Initial Research Areas |
Immunology |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.