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Phospho-MUSK (Tyr755) Antibody

Phospho-MUSK (Tyr755) Antibody

Item no.	CSB-PA204567
Manufacturer	Cusabio
Amount	100ul
Category	Antibodies Western Blot ELISA Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA
Specific against	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CMS9 antibody; FADS antibody; MDK 4 antibody; MDK4 antibody; MGC126323 antibody; MGC126324 antibody; Muscle antibody; Muscle associated receptor tyrosine kinase antibody; Muscle skeletal receptor tyrosine kinase antibody; Muscle skeletal receptor tyrosine protein kinase antibody; Muscle specific kinase receptor antibody; Muscle specific tyrosine kinase receptor antibody; Muscle specific tyrosine protein kinase receptor antibody; Muscle-specific kinase receptor antibody; Muscle-specific tyrosine-protein kinase receptor antibody; MuSK antibody; MUSK_HUMAN antibody; Neural fold somite kinase 1 antibody; Neural fold somite kinase 2 antibody; Neural fold somite kinase 3 antibody; Neural fold somite kinase1 antibody; Neural fold somite kinase2 antibody; Neural fold somite kinase3 antibody; Nsk 1 antibody; Nsk 2 antibody; Nsk 3 antibody; Nsk1 antibody; Nsk2 antibody; Nsk3 antibody; Receptor tyrosine kinase MuSK antibody; Skeletal muscle receptor tyrosine kinase antibody; skeletal receptor tyrosine-protein kinase antibody, MUSK, Muscle, skeletal,
Similar products	MUSK, Muscle, skeletal
Available
Immunogen Species	Human
UniprotID	O15146
Immunogen	Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK .
Applications info	ELISA, WB, WB:1:500-1:1000
Dilution ratio 1	ELISA:1:2000-1:10000
Dilution ratio 2	WB:1:500-1:1000
Background	Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. Valenzuela D.M., Neuron 15:573-584(1995). Humphray S.J., Nature 429:369-374(2004). Bergamin E., Mol. Cell 39:100-109(2010).
Conjugate	Non-conjugated
Buffer	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage	Upon receipt, store at -20C or -80C. Avoid repeated freeze.
Purification Method	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
General Research Areas	Tags & Cell Markers, Signal transduction
Initial Research Areas	Signal Transduction

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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