TNF Antibody

P01375

ELISA, IHC, IF, IHC:1:50-1:100, IF:1:100-1:500

IHC:1:50-1:100

Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.

Neville M.J., J. Immunol. 162:4745-4754(1999).
Xie T., Genome Res. 13:2621-2636(2003).
Kim Y.J., Hum. Mol. Genet. 12:2541-2546(2003).

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunology