Item no. |
CSB-PA123981 |
Manufacturer |
Cusabio
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
WB, ELISA |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
MGC138871 antibody; ADHD7 antibody; FLJ37295 antibody; MGC138872 antibody; Neuronal tryptophan hydroxylase antibody; NTPH antibody; TPH 2 antibody; Tph2 antibody; TPH2_HUMAN antibody; Tryptophan 5-hydroxylase 2 antibody; Tryptophan 5-monooxygenase 2 antibody; Tryptophan hydroxylase 2 antibody, ADHD7, NTPH, TPH2, |
Similar products |
TPH2, ADHD7, NTPH |
Available |
|
Immunogen Species |
Human |
UniprotID |
Q8IWU9 |
Immunogen |
Peptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2. |
Applications info |
ELISA, WB, WB:1:500-1:1000 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
WB:1:500-1:1000 |
Background |
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
Walther D.J., Science 299:76-76(2003). Scherer S.E., Nature 440:346-351(2006).
|
Conjugate |
Non-conjugated |
Buffer |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
General Research Areas |
Neuroscience |
Initial Research Areas |
Neuroscience |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.