AKAP12 Antibody

Q02952

ELISA, WB, IHC, ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:50-1:200

WB:1:200-1:1000

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

-20C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Antigen affinity purification

Signal Transduction