Item no. |
CSB-PA097577 |
Manufacturer |
Cusabio
|
Amount |
100ul |
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
WB, IF, IHC, ELISA |
Specific against |
Human, Mouse |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
APG4 autophagy 4 homolog C (S. cerevisiae) antibody; APG4 autophagy 4 homolog C antibody; APG4 C antibody; APG4-C antibody; APG4C antibody; ATG 4C antibody; ATG4 autophagy related 4 homolog C (S. cerevisiae) antibody; ATG4 autophagy related 4 homolog C antibody; Atg4c antibody; ATG4C_HUMAN antibody; AUT (S. cerevisiae) like 1; cysteine endopeptidase antibody; AUT like 1; cysteine endopeptidase (S. cerevisiae) antibody; AUT like 1; cysteine endopeptidase antibody; AUT like 3 cysteine endopeptidase antibody; AUT-like 3 cysteine endopeptidase antibody; AUTL1 antibody; AUTL3 antibody; Autophagin 3 antibody; Autophagin-3 antibody; Autophagy related 4C cysteine peptidase antibody; Autophagy related cysteine endopeptidase 3 antibody; Autophagy related protein 4 homolog C antibody; Autophagy-related cysteine endopeptidase 3 antibody; Autophagy-related protein 4 homolog C antibody; Cysteine protease ATG4C antibody; EC 3.4.22 antibody; FLJ14867 antibody; OTTHUMP00000010715 antibody, APG4 autophagy 4 homolog C, APG4-C, APG4C, AUT-like 3 cysteine endopeptidase, AUTL1 |
Similar products |
AUTL1, APG4C, AUT-like 3 cysteine endopeptidase, APG4-C, APG4 autophagy 4 homolog C |
Available |
|
Immunogen Species |
Human |
UniprotID |
Q96DT6 |
Immunogen |
Synthesized peptide derived from internal of human ATG4C. |
Applications info |
ELISA, WB, IHC, IF, WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
WB:1:500-1:3000 |
Dilution ratio 3 |
IHC:1:50-1:100 |
Dilution ratio 4 |
IF:1:100-1:500 |
Background |
Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required for a proper autophagic response under stressful conditions such as prolonged starvation By similarity. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
Marino G., J. Biol. Chem. 278:3671-3678(2003). Chen J.M., Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. Ota T., Nat. Genet. 36:40-45(2004). |
Conjugate |
Non-conjugated |
Buffer |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
General Research Areas |
Cancer?Cardiovascular?Cell biology, Metabolism, Signal transduction |
Initial Research Areas |
Cancer |
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.