Item no. |
CSB-PA006589LA01HU-50ug |
Manufacturer |
Cusabio
|
Amount |
50ug |
Quantity options |
100ug
20ug
50ug
|
Category |
|
Type |
Antibody Polyclonal |
Format |
Liquid |
Applications |
IF, IHC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
C/EBP homologous protein antibody; C/EBP Homology Protein antibody; C/EBP zeta antibody; C/EBP-homologous protein 10 antibody; C/EBP-homologous protein antibody; CCAAT/enhancer binding protein homologous protein antibody; CEBPZ antibody; CHOP 10 antibody; CHOP antibody; CHOP-10 antibody; CHOP10 antibody; DDIT 3 antibody; DDIT-3 antibody; Ddit3 antibody; DDIT3_HUMAN antibody; DNA Damage Inducible Transcript 3 antibody; DNA damage-inducible transcript 3 protein antibody; GADD 153 antibody; GADD153 antibody; Growth Arrest and DNA Damage Inducible Protein 153 antibody; Growth arrest and DNA damage inducible protein GADD153 antibody; Growth arrest and DNA damage-inducible protein GADD153 antibody; MGC4154 antibody, DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153), DDIT3, CHOP CHOP10 GADD153 |
Similar products |
DDIT3, DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153), CHOP CHOP10 GADD153 |
Available |
|
Immunogen Species |
Human |
UniprotID |
P35638 |
Immunogen |
Recombinant Human DNA damage-inducible transcript 3 protein (1-169AA) |
Applications info |
ELISA, IHC, IF, Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 |
Dilution ratio 1 |
ELISA:1:2000-1:10000 |
Dilution ratio 2 |
IHC:1:20-1:200 |
Dilution ratio 3 |
IF:1:50-1:200 |
Background |
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates, expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response. |
Conjugate |
Non-conjugated |
Buffer |
Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
Storage |
Upon receipt, store at -20C or -80C. Avoid repeated freeze. |
Purification Method |
>95%, Protein G purified |
General Research Areas |
Epigenetics and Nuclear Signaling, Developmental biology, Metabolism, Stem cells |
Initial Research Areas |
Epigenetics and Nuclear Signaling |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.